In order to properly organize and set scope domains for scientific abstracts covering activity of various enzyme inhibitors, the Ki and IC50 values commonly reported must be integrated into a data-set which can be directly compared. This is done so that some idea of the strength of the inhibitor can be comprehended, being mindful that the biochemistry involved is extremely complex and inter-related with other chemistry mechanism involving signal transduction and homeo-static response.

The takeaway being that the values above must be known except for either Ki or IC50 depending on which way you want to solve the conversion, and they all must be in the same units; e.g. molar, millimolar, micromolar or nanomolar.

Then reviewing pharmacokinetics, it seems that the area under the graph would indicate how much “pressure” the compound exerts on shifting the homeostatic condition, and therefore would be related to how much the body responds by un and downregulating various enzymes, expressing new enzymes and other cellular mechanisms.