{"id":402,"date":"2023-11-13T04:12:15","date_gmt":"2023-11-13T04:12:15","guid":{"rendered":"https:\/\/sparkonelabs.com\/home\/?p=402"},"modified":"2023-11-13T04:28:33","modified_gmt":"2023-11-13T04:28:33","slug":"science-literature-review-and-education-on-maths","status":"publish","type":"post","link":"https:\/\/sparkonelabs.com\/home\/2023\/11\/13\/science-literature-review-and-education-on-maths\/","title":{"rendered":"Science Literature: Review and Education on Maths"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">In order to properly organize and set scope domains for scientific abstracts covering activity of various enzyme inhibitors, the Ki and IC50 values commonly reported must be integrated into a data-set which can be directly compared. This is done so that some idea of the strength of the inhibitor can be comprehended, being mindful that the biochemistry involved is extremely complex and inter-related with other chemistry mechanism involving signal transduction and homeo-static response.<\/p>\n\n\n\n<figure class=\"wp-embed-aspect-16-9 wp-has-aspect-ratio wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube\"><div class=\"wp-block-embed__wrapper\">\n<iframe title=\"comparing potency values with the Cheng-Prusoff equation\" width=\"1170\" height=\"658\" src=\"https:\/\/www.youtube.com\/embed\/9bTvyKruiZ0?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" allowfullscreen><\/iframe>\n<\/div><figcaption class=\"wp-element-caption\">Video on Ki and IC50 values<\/figcaption><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><img data-recalc-dims=\"1\" fetchpriority=\"high\" decoding=\"async\" width=\"1024\" height=\"576\" src=\"https:\/\/i0.wp.com\/sparkonelabs.com\/home\/wp-content\/uploads\/2023\/11\/Screenshot_20231112_231208.png?resize=1024%2C576&#038;ssl=1\" alt=\"\" class=\"wp-image-403\" srcset=\"https:\/\/i0.wp.com\/sparkonelabs.com\/home\/wp-content\/uploads\/2023\/11\/Screenshot_20231112_231208.png?resize=1024%2C576&amp;ssl=1 1024w, https:\/\/i0.wp.com\/sparkonelabs.com\/home\/wp-content\/uploads\/2023\/11\/Screenshot_20231112_231208.png?resize=300%2C169&amp;ssl=1 300w, https:\/\/i0.wp.com\/sparkonelabs.com\/home\/wp-content\/uploads\/2023\/11\/Screenshot_20231112_231208.png?resize=768%2C432&amp;ssl=1 768w, https:\/\/i0.wp.com\/sparkonelabs.com\/home\/wp-content\/uploads\/2023\/11\/Screenshot_20231112_231208.png?resize=1536%2C864&amp;ssl=1 1536w, https:\/\/i0.wp.com\/sparkonelabs.com\/home\/wp-content\/uploads\/2023\/11\/Screenshot_20231112_231208.png?w=1920&amp;ssl=1 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">The takeaway being that the values above must be known except for either Ki or IC50 depending on which way you want to solve the conversion, and they all must be in the same units; e.g. <em>molar, millimolar, micromolar or nanomolar<\/em>.<\/p>\n\n\n\n<figure class=\"wp-embed-aspect-16-9 wp-has-aspect-ratio wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube\"><div class=\"wp-block-embed__wrapper\">\n<iframe title=\"the difference between drug potency &amp; efficacy\" width=\"1170\" height=\"658\" src=\"https:\/\/www.youtube.com\/embed\/c_epF8LiP4U?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" allowfullscreen><\/iframe>\n<\/div><figcaption class=\"wp-element-caption\">Potency vs. Efficacy<\/figcaption><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Then reviewing pharmacokinetics, it seems that the area under the graph would indicate how much &#8220;pressure&#8221; the compound exerts on shifting the homeostatic condition, and therefore would be related to how much the body responds by un and downregulating various enzymes, expressing new enzymes and other cellular mechanisms. <\/p>\n\n\n\n<figure class=\"wp-embed-aspect-16-9 wp-has-aspect-ratio wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube\"><div class=\"wp-block-embed__wrapper\">\n<iframe title=\"Pharmacokinetics 1 - Introduction\" width=\"1170\" height=\"658\" src=\"https:\/\/www.youtube.com\/embed\/8-Qtd6RhfVA?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" allowfullscreen><\/iframe>\n<\/div><figcaption class=\"wp-element-caption\">Pharmacokinetics<\/figcaption><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>In order to properly organize and set scope domains for scientific abstracts covering activity of various enzyme inhibitors, the Ki and IC50 values commonly reported must be integrated into a data-set which can be directly compared. This is done so that some idea of the strength of the inhibitor can be comprehended, being mindful that<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"nf_dc_page":"","om_disable_all_campaigns":false,"pagelayer_contact_templates":[],"_pagelayer_content":"","_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_hide_featured_image":false,"_jetpack_featured_image_duplicate_dismissed":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-402","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Science Literature: Review and Education on Maths - SparkOne() Labs Official Site<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sparkonelabs.com\/home\/2023\/11\/13\/science-literature-review-and-education-on-maths\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Science Literature: Review and Education on Maths - SparkOne() Labs Official Site\" \/>\n<meta property=\"og:description\" content=\"In order to properly organize and set scope domains for scientific abstracts covering activity of various enzyme inhibitors, the Ki and IC50 values commonly reported must be integrated into a data-set which can be directly compared. 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